The Therapeutic Effects of Moringa pterygosperma Extract on Type 2 Diabetes: Modulation of TNF-α, Oxidative Stress, and Liver Function Biomarkers

Abstract

The Type 2 diabetes mellitus is considered as a metabolic disorder which included chronic hyperglycemia, insulin resistance, and systemic inflammation, oxidative stress and liver dysfunction. Natural plant therapies, as Moringa pterygosperma (Moringa oleifera) have gained attention for their potential role in managing diabetes which is rich to phytochemical and medicinal properties. This present study aimed to investigate the protective and important role of Moringa pteridosperms extracts in reducing oxidative stress, inflammation, and hepatic dysfunction against the alloxan, which induced diabetic rats, by evaluating the levels of, Tumor Necrosis Factor-alpha, Malondialdehyde, Total Antioxidant Capacity, Alanine Aminotransferase, and Aspartate Aminotransferase. The study included forty adult male albino Wistar rats was divided into equal four groups included: a control group (C), a Diabetic (N) indicated by alloxan injection, a Treatment Group (T1) indicated by diabetic rats treated with 100 mg/kg Moringa extract, and Treatment Group (T2) indicated by the diabetic rats treated with 200 mg/kg Moringa extract. Blood glucose levels were monitored, and biochemical markers were analyzed using ELISA and spectrophotometric assays. Moringa extraction supplementation showed a significant decrease in blood glucose levels and reduced TNF-α and MDA levels, indicating decreased inflammation and oxidative stress compared with induction group (N). Additionally, the T1 and T2 showed an increase in TAC levels, which illustrated the improved antioxidant defense and liver function. The present study results proved that Moringa pterygosperma extract plays a critical role in maintaining diabetic, oxidant stress, and protecting the hepatic cell. In additionally the results illustrated the ability of use the Moringa as a natural protective for diabetes, in animal and humans.