Instrumental Techniques of Pharmaceuticals Analysis: A Review
DOI:
https://doi.org/10.51699/cejsr.v45i1.428Keywords:
Mass Spectroscopy, NMR, HPLC, Chromatography, UV Vis Spectroscopy, GC Mass, Atomic Absorption SpectroscopiesAbstract
Pharmaceutical analysis is the branch of analysis that is concerned with the qualitative and quantitative examination of drugs and other pharmaceutical products with respect to their use, safety and efficacy, and regulatory compliance. It is an important part of the pharmaceutical industry and is essential for the progress of the drug development, manufacturing, and marketing. The study of analysis includes a wide range of methods and techniques which are used to determine the elements of drug substances and drug products. Such methods are conventionally classified into two major types: chemical analysis and instrumental analysis. Chemical Analysis: It includes laboratory methods which seek the identification and measurement of chemical species stipulated in the pharmaceuticals. These techniques comprise of titration methods, gravimetric techniques, and colorimetry. Chemical tests identify the certain functional groups, impurities, and chemical reactions which are pertinent to the particular properties of the drug. Instrumental Analysis: Instrumental analysis makes use of modern sophisticated instruments to measure the drugs with great precision, sensitivity, and accuracy. Chromatography HPLC and GC, spectroscopes UV Vish, IR and NMR, mass spectrometer MS, and atomic absorption spectroscopies AAS are in common use. The methods make it possible to separate, identify and determine the amounts of active pharmaceutical ingredients APIs, their degradation products, and the impurities. These methods are important for the evaluation of the quality of drugs and for the maintenance of appropriate uniformity and consistency of the product throughout the pharmaceutical processes and regulatory procedures. The pharmaceutical analysis also includes the measurements of rates of drug dissolution and rates of drug release from solid dosage forms because those parameters affect drug efficacy and bioavailability in a major degree. Additionally, stability testing is conducted to assess the shelf Life of pharmaceutical products under various storage conditions.
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Copyright (c) 2025 Ali Jabbar Radhi, I. Alrubaie, Ahmed Ridha Abduljawad, Jawad Alshams, Farked Wahoodi Salman, Emad Kadhim Atiyah, Hayder K. Khattar, Hussein Abdulkadhim Hasan, Ahmed Neamah Thamer Al-Yasiri, Muhand Dohan Abid
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