A Revision of Fundamental Issues With Using Dialysis To Treat Chronic Kidney Insufficiency
Keywords:
End-Stage Renal Illness, Glomerular Filtration Rate, Cardiovascular Risk, Dialysis, Hypertension, Chronic Renal FailureAbstract
The current paper reviews chronic renal failure (CRF), a major public health disease that affects the elderly globally. The Chronic Renal Failure (CRF) is primarily caused by compromised kidney function. The glomerular filtration rate (GFR) divides CRF into five stages. Dialysis is the most effective therapy for end-stage renal disease (ESRD), which occurs when a person's GFR is less than 15 ml/min/1.73 m² due to chronic renal failure. Patients undergoing dialysis face a 10–20 times higher cardiovascular risk due to inflamed kidneys and the dialysis technique, which exacerbates hypertension and cardiovascular complications. As a result, both physicians and patients should understand the implications of dialysis, especially for chronic renal failure patients, who need immediate education on the disease, its medications, dietary guidelines, and other essential measures. Accordingly, the current review is an attempt to reveal the processes that may contribute to cardiovascular and other complications in dialysis patients with CRF.
References
Sabitha V, Venkataramana K: Dialysis: A Review of the Mechanisms Underlying Complications in the Management of Chronic Renal Failure. Cureus.2017, 9(8): 1603.
Lee KY: A unified pathogenesis for kidney diseases, including genetic diseases and cancers, by the protein-homeostasis-system hypothesis. Kidney Res Clin Pract. 2017, 36:132-144.
Tattersall J, Dekker F, Heimburger O, et al.: When to start dialysis: updated guidance following the publication of the Initiating Dialysis Early and Late (IDEAL) study. Nephrol Dial Transplant. 2011, 26:2082-2086.
Aziz HJ, Narjis HA: Biochemical Markers of Bone Turnover in Pre-dialysis, Chronic Renal Failure Patients. Researh J Pharm and Tech. 2019, 12 (10):1-4.
Inker LA, Astor BC, Fox CH, et al.: KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. Am J Kidney Dis. 2014, 63:713-735.
Description of High Blood Pressure . (2015). Accessed: March 25, 2017: https://www.nhlbi.nih.gov/health/health-topics/topics/hbp.
Foley RN, Collins AJ: End-stage renal disease in the United States: an update from the United States Renal Data System. J Am Soc Nephrol. 2007, 18:2644-2648.
Lackland DT, Weber MA: Global burden of cardiovascular disease and stroke: hypertension at the core. Can J Cardiol. 2015, 31:569-571.
Stegmayr B: Dialysis procedures alter metabolic conditions. Nutrients. 2017, 9:548.
Ifudu O: Care of patients undergoing hemodialysis. N Engl J Med. 1998, 339:1054-1062.
Schiffl H, Lang SM, Fischer R: Daily hemodialysis and the outcome of acute renal failure . N Engl J Med. 2002, 346:305-310.
Nagane NS, Ganu JV, Jagtap PE: Study of oxidative stress in pre- and post-hemodialysis in chronic renal failure patients. strength physical exercise on oxidative stress and inflammatory responses in hemodialysis patients. Biomedical Research. 2013, 24:498-502.
Macunluoglu B, Gumrukcuoglu HA, Atakan A, et al.: Lowering dialysate sodium improves systemic oxidative stress in maintenance hemodialysis patients. Int Urol Nephrol. 2016,48:1699-1704.
Harnett JD, Foley RN, Kent GM, Barre PE, Murray D, Parfrey PS: Congestive heart failure in dialysis patients: prevalence, incidence, prognosis and risk factors. Kidney Int. 1995, 47:884-890.
Volodarskiy A, Kumar S, Amin S, Bangalore S: Optimal treatment strategies in patients with chronic kidney disease and coronary artery disease. Am J Med. 2016, 129:1288-1298.
Braunlich H: Postnatal development of kidney function in rats receiving thyroid hormones .Exp Clin Endocrinol. 1984, 83:243-250.
Dubczak I, Niemczyk L, Bartoszewicz Z, Szamotulska K, Saracyn M, Niemczyk S: The influence of hypothyroidism on the conversion and binding of thyroid hormones in patients with end-stage renal disease (Article in Polish). Pol Merkur Lekarski. 2017, 42:101-105.
Dunne A, O'Neill LA: The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE. 2003, 2003:re3.
Chen WY, Li LC, Yang JL: Emerging roles of IL-33/ST2 axis in renal diseases . Int J Mol Sci. 2017, 18:783.
Zoccali C, Tripepi G, Cutrupi S, Pizzini P, Mallamaci F: Low triiodothyronine: a new facet of inflammation in end-stage renal disease. J Am Soc Nephrol. 2005, 16:2789-2795.
Yilmaz MI, Sonmez A, Saglam M, et al.: ADMA levels correlate with proteinuria, secondary amyloidosis, and endothelial dysfunction. J Am Soc Nephrol. 2008, 19:388-395.
Matsuguma K, Ueda S, Yamagishi S, et al.: Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. J Am Soc Nephrol. 2006, 17:2176-2183.
Vaziri ND: Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences. Am J Physiol Renal Physiol. 2006, 290:262-272.
Weber GJ, Pushpakumar S, Tyagi SC, Sen U: Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension. Pharmacol Res. 2016, 113 (Pt A):300-312.
Kang AH, Trelstad RL: A collagen defect in homocystinuria . J Clin Invest. 1973, 52:2571-2578.
Goodman WG, Goldin J, Kuizon BD, et al.: Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000, 342:1478-1483.
Bernardi S, Toffoli B, Bossi F, et al.: Circulating osteoprotegerin is associated with chronic kidney disease in hypertensive patients. BMC Nephrol. 2017, 18:219.
Gohda T, Maruyama S, Kamei N, et al.: Circulating TNF receptors 1 and 2 predict mortality in patients with end-stage renal disease undergoing dialysis. Scientific Reports. 2017, 7:43520.
Jofre R, Rodriguez-Benitez P, Lopez-Gomez JM, Perez-Garcia R: Inflammatory syndrome in patients on hemodialysis. J Am Soc Nephrol. 2006, 17:274–280.
Elliott TL: Electrolytes: potassium disorders . FP Essent. 2017, 459:21-28.
Weaver DJ Jr, Somers MJG, Martz K, Mitsnefes MM: Clinical outcomes and survival in pediatric patients initiating chronic dialysis: a report of the NAPRTCS registry. Pediatr Nephrol. 2017,1-12.
Han SS, Ryu DR, Joo KW, et al.: Risk of stroke in elderly dialysis patients . J Korean Med Sci.
, 32:1460-1467.