Integrated Management of Post-Myocardial Infarction Patients Using Genetic Analysis and Remote Control
DOI:
https://doi.org/10.51699/emjms.v26i4.5Keywords:
sudden coronary death, stenosis, coronary arteriesAbstract
Coronary heart disease (CHD) remains a leading cause of mortality and morbidity worldwide, particularly due to complications following myocardial infarction (MI). Despite advancements in therapeutic strategies, the prognosis for MI patients varies significantly, necessitating a comprehensive approach that integrates genetic and non-genetic factors. This study addresses the knowledge gap by evaluating the influence of genetic polymorphisms and non-genetic factors on the 12-month prognosis of MI patients. Using a cohort of 250 post-MI patients, we conducted genetic analysis on polymorphisms of the AGT, ADRB1, APOE, LPL, and CYP2C19 genes and assessed their correlation with clinical outcomes using modern statistical methods. Our findings indicate significant associations between specific gene polymorphisms and patient prognosis, highlighting the importance of personalized medicine. The results suggest that incorporating genetic analysis into the management of MI patients can improve survival rates and inform targeted therapeutic interventions, offering a novel approach to enhancing patient care in clinical settings.
References
F. Shernazarov, J. Tohirova, and D. Jalalova, "Types of Hemorrhagic Diseases, Changes in Newborns, Their Early Diagnosis," Science and Innovation, vol. 1, no. D5, pp. 16-22, 2022.
D. Z. Zhalalova, "The Content of Endothelin and Homocysteine in Blood and Lacrimal Fluid in Patients With Hypertensive Retinopathy," Web of Scientist: International Scientific Research Journal, vol. 2, pp. 958-963, 2022.
D. Jalalova, X. Raxmonov, and F. Shernazarov, "The Role of C-Reactive Protein in the Pathogenesis of Visual Vascular Diseases in Patients With Arterial Hypertension," Science and Innovation, vol. 1, no. 8, pp. 114-121, 2022, doi: https://doi.org/10.5281/zenodo.7335637.
D. Jalalova, X. Raxmonov, and F. Shernazarov, "Significance of Endothelial Dysfunction in the Development of Retinopathy in Patients With AH and Ways of Its Correction," Science and Innovation, vol. 1, no. 8, pp. 101-113, 2022, doi: https://doi.org/10.5281/zenodo.7335616.
F. Shernazarov and J. D. Zuhridinovna, "Microcirculation Disorders in the Vascular System of the Bulbar Conjunctiva in the Initial Manifestations of Cerebral Blood Supply Deficiency," Science and Innovation, vol. 1, Special Issue 2, pp. 515-522, 2022.
D. Jalalova, N. Normatova, and F. Shernazarov, "Genetic Markers for the Development of Diabetic Retinopathy," Science and Innovation, vol. 1, no. 8, pp. 919-923, 2022, doi: https://doi.org/10.5281/zenodo.7443019.
A. Narbaev, Z. Djuraeva, N. Kurbovona, G. Kuvondikov, A. Davranova, and S. Sodikov, "Особенности изучения многофакторного управления сахарным диабетом 2 типа," Журнал Проблемы Биологии и Медицины, no. 4 (97), pp. 78-79, 2017.
X. Xamraev, S. Sodikov, D. Xamraeva, and D. Sobirova, "Клинико-функциональное состояние печени у больных с сахарным диабетом," Журнал Проблемы Биологии и Медицины, no. 1 (99), pp. 189-191, 2018.
S. Sodikov, N. Karimova, and Z. Karimova, "Реабилитация больных пожилого возраста сахарным диабетом 2-типа," Журнал Проблемы Биологии и Медицины, no. 4 (97), pp. 105-106, 2017.
M. N. Xamidova, I. F. Ismatova, J. S. Berdierov, G. Sh. Negmatova, and A. T. Daminov, "Сахарный диабет и COVID-19," Eurasian Journal of Medical and Natural Sciences, vol. 2, no. 13, pp. 190-204, 2022.
S. D. Shuxratovna, Y. U. Kakhramonovich, and K. T. Mahmudovich, "Структурные изменения сосудисто-стромального комплекса щитовидной железы при эутиреоидной и токсических формах зоба," Научный Журнал, no. 10 (44), pp. 67-69, 2019.
K. N. Sobirzjonovna, S. S. Salloxidinov, and M. O. Akbarovna, "Эпидемиологический Статус И Факторы Риска Сахарного Диабета На Сегодняшний День," Miasto Przyszłości, vol. 32, pp. 212-219, 2023.
D. E. Salimova and A. T. Daminnov, "A Clinical Case Based on the Experience of Treating Hypertension in a Patient With Type 2 Diabetes Mellitus, Obesity and Vitamin D Deficiency," Educational Research in Universal Sciences, vol. 2, no. 12, pp. 150-154, 2023.
D. A. Takhirovich, "Assessment of Hearing Function in Individuals With Type 2 Diabetes," American Journal of Pediatric Medicine and Health Sciences, vol. 1, no. 9, pp. 124-126, 2023.
R. J. Alimdjanovich, K. Z. Babajanovich, S. Z. Bahadirovich, and A. D. Shukurullaevich, "Антеградная ангиосклеротерапия левой тестикулярной вены," Journal of Biomedicine and Practice, vol. 8, no. 4, accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/biomedicine/article/view/8309.
P. B. G, R. A. J, X. L. N, and K. T. Boboev, "Полиморфизм гена MTHFR (A1298C) и врожденные пороки челюстно-лицевой области," Conferences, published online November 10, 2023, pp. 62-63.
M. J. Saadh, M. A. Mustafa, S. Kumar, et al., "Advancing Therapeutic Efficacy: Nanovesicular Delivery Systems for Medicinal Plant-Based Therapeutics," Naunyn-Schmiedeberg’s Archives of Pharmacology, published online May 3, 2024, doi: 10.1007/s00210-024-03104-9. DOI: https://doi.org/10.1007/s00210-024-03104-9
A. Allayarov, J. Rizaev, and A. Yusupov, "Advantages of Laser Treatment of Diabetic Retinopathy: Analysis of Clinical Data," Science and Innovation, vol. 3, no. D4, pp. 142-145, 2024.
A. A. Patel, A. H. Mohamed, J. Rizaev, et al., "Application of Mesenchymal Stem Cells Derived From the Umbilical Cord or Wharton’s Jelly and Their Extracellular Vesicles in the Treatment of Various Diseases," Tissue and Cell, vol. 89, p. 102415, 2024, doi: https://doi.org/10.1016/j.tice.2024.102415. DOI: https://doi.org/10.1016/j.tice.2024.102415
J. A. Rizaev and M. Sh. Ergashova, "Bolalarda Neyroinfektsiyadan Keyin Kelib Chiqadigan Nogironlikning Tibbiy Jihatlarini Tahlil Qilish," САПАПКИ, vol. 1, no. 1, pp. 32-33, 2024.
A. Allayarov, J. Rizaev, and A. Yusupov, "Clinical Efficacy of Laser Treatment of Diabetic Retinopathy," Science and Innovation, vol. 3, no. D4, pp. 138-141, 2024.
D. Alieva, J. Rizaev, and A. Sadikov, "COVID-19 Pandemic and Analysis of the Current Epidemiological Situation in Uzbekistan and Neighbouring Countries of Central Asia and the World (Analytical Review)," Young Scholar’s Academic Journal, vol. 3, no. 2, pp. 16-29, 2024.
R. J. Alimdjanovich, Q. O. Shakirdjanovich, K. A. Isamiddinovich, and R. M. A. Kizi, "Dynamics of Local Immunity of the Oral Cavity at the Stages of Treatment," Naturalista Campano, vol. 28, no. 1, pp. 2335-2337, 2024.
D. A. Alieva, J. A. Rizaev, and A. A. Sadikov, "Epidemiological Assessment of the COVID-19 Situation Among the Sports Community," EPRA International Journal of Research and Development (IJRD), vol. 9, no. 5, pp. 376-379, 2024. DOI: https://doi.org/10.36713/epra17107
A. S. Blagonravova, B. S. A., J. A. Rizaev, R. J. A., O. S. Gileva, and G. O. S., "Horizons of International Cooperation: Medical Science, Practice and Education," Perm Medical Journal, vol. 41, no. 1, pp. 168-170, 2024, doi: https://doi.org/10.17816/pmj411168-170. DOI: https://doi.org/10.17816/pmj411168-170
R. J. Alimdjanovich, Q. O. Shakirdjanovich, K. A. Isamiddinovich, and R. M. A. Kizi, "Stress and Periodontal Disease (Review Article)," Naturalista Campano, vol. 28, no. 1, pp. 2338-2342, 2024.
J. A. Rizaev, A. M. Sh, A. S. Kubaev, and A. I. Hazratov, "Morphological Changes in the Oral Mucous Membrane in Patients With COVID-19," American Journal of Medicine and Medical Sciences, vol. 12, no. 5, pp. 466-470, 2022.
A. S. Kubaev, Sh. G. Karshiev, and B. Bazarov, "Наш опыт хирургического лечения переломов нижней челюсти," Журнал Биомедицины и Практики, vol. 7, no. 1, 2022.
D. D. Maqsudov, A. S. Kubaev, and D. D. Maksudov, "Вирусли Гепатитнинг В Тури Билан Огриган Беморларнинг Юз-Жаг Сохасидаги Флегмоналарни Комплекс Даволаш Дастури," Биология, no. 4, pp. 137, 2022.
J. A. Rizaev, A. S. Abdullaev, and A. S. Kubaev, "Перспективы Лечения Невритов В Комплексе С Этилметилгидроксипиридина Сукцинат И Комбилипен," in Современная Медицина: Новые Подходы И Актуальные Исследования, pp. 20-24, 2022.
M. M. Khikmatuloevna, K. A. Saidolimovich, and H. A. Isomiddinovich, "Analysis of Occlusal-Articulatory Relationship in Patients With Temporomandibular Joint Dysfunction Syndrome," Conferencea, published online May 26, 2022, pp. 195-196.
M. X. Marupova, A. S. Kubaev, and A. I. Khazratov, "Diagnosis and Treatment of Pain Syndrome in Temporomandibular Joint Dysfunction Syndrome," Central Asian Academic Journal of Scientific Research, vol. 2, no. 5, pp. 109-112, 2022.
N. N. Elbekovna, M. I. Mukhamedovich, and Kh. L. Emilievna, "Study of Microflora Sensitivity in the Oral Cavity of Patients Undergoing Removable and Non-Removable Orthodontic Treatment Using Certain Drugs," Journal of Stomatology and Craniofacial Research, vol. 3, no. 2, 2022. Accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/oral/article/view/5013
G. P. Bakhtiyorovich, R. J. Alimjanovich, Kh. N. Lukmonovich, and B. K. Tukhtaevich, "Features of Allelic Polymorphism Ile462Val in the CYP1A1 Gene Among Patients With Congenital Jaw-Facial Anomalies," Journal of Stomatology and Craniofacial Research, vol. 4, no. 4, 2023. Accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/oral/article/view/8226
R. J. Alimjanovich, M. O. Akbarovna, and D. N. Rustamovna, "Features of Clinical Symptoms and Functional State of the Respiratory System in Patients With Rapidly Progressing Periodontitis in Comorbid Condition," Conferencea, published online February 11, 2023, pp. 40-44.
R. J. Alimjanovich, S. M. Abdurakhmonovich, and Kh. F. Olimovna, "Evaluation of the Awareness of Family Doctors, Cardiologists, and Therapists About High-Tech Medical Care Using Telemedicine Technologies in Samarkand Region," JSML, vol. 1, no. 2, pp. 102-105, 2023.
J. A. Rizaev, R. D. Abdurakhmonovich, M. O. Akbarovna, and N. R. Dustmurodovich, "Parallels of Immunological and Clinical Indicators in Patients With Bronchial Asthma With Comorbid Pathology of the Oral Cavity," European Journal of Interdisciplinary Research and Development, vol. 12, pp. 96-103, 2023.
G. P. Bakhtiyorovich, R. J. Alimjanovich, Kh. N. Lukmonovich, and B. K. Tukhtaevich, "Polymorphic Genes of the Folate Cycle and Congenital Anomalies of the Jaw-Facial Region," Journal of Stomatology and Craniofacial Research, vol. 4, no. 4, 2023. Accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/oral/article/view/8220
A. A. Sarkhadovich, K. A. Saidalimovich, and R. J. Alimjanovich, "Threshold of Excitability in Neuritis of the Inferior Alveolar Nerve," Journal of Biomedicine and Practice, vol. 7, no. 4, 2022. Accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/biomedicine/article/view/5521
M. X. Marupova, A. S. Kubaev, and A. I. Khazratov, "Improvement of Diagnostic and Treatment Methods for Patients With Temporomandibular Joint Pain Dysfunction Syndrome," Eurasian Journal of Medical and Natural Sciences, vol. 2, no. 5, pp. 164-167, 2022.
J. A. Rizaev, M. Sh. Akhrorova, A. S. Kubaev, and A. I. Khazratov, "Changes in the Mucous Membranes of the Oral Cavity in Patients Depending on the Clinical Course of COVID-19," Journal of Stomatology and Craniofacial Research, vol. 3, no. 1, 2022. Accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/oral/article/view/7158
R. J. Alimjanovich, A. M. Shavkatovna, K. A. Saidolimovich, and K. A. Isamiddinovich, "Clinical and Immunological Aspects of the Relationship of the Oral Cavity and COVID-19," Thematics Journal of Education, vol. 7, no. 2, 2022. Accessed June 14, 2024. [Online]. Available: https://thematicsjournals.in/index.php/tjed/article/view/1024
M. X. Marupova, A. S. Kubaev, and A. I. Khazratov, "Diagnosis and Treatment of Pain Syndrome in Temporomandibular Joint Dysfunction Syndrome," Vestnik Magistratury, no. 5-1 (128), pp. 10-11, 2022.
R. J. Alimjanovich and E. M. Yakubovna, "Medico-Social Aspects of Childhood Disability," Journal of Biomedicine and Practice, vol. 8, no. 3, 2023. Accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/biomedicine/article/view/7705
N. Ghasemi Darestani, A. I. Gilmanova, M. E. Al-Gazally, et al., "Mesenchymal Stem Cell-Released Oncolytic Virus: An Innovative Strategy for Cancer Treatment," Cell Communication and Signaling, vol. 21, no. 1, p. 43, 2023, doi: https://doi.org/10.1186/s12964-022-01012-0. DOI: https://doi.org/10.1186/s12964-022-01012-0
M. F. Isamiddinovich, K. A. Saidalimovich, and P. B. Jurakhonovna, "Clinical and Immunological Characteristics of Phlegmons in the Jaw-Facial Region With Metabolic Syndrome," Journal of Stomatology and Craniofacial Research, vol. 3, no. 4, 2022. Accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/oral/article/view/7016
R. J. Alimjanovich and K. A. Saidalimovich, "Sociological Assessment of Orthopedic Dental Care for Patients With Acquired Jaw-Facial Defects," Journal of Stomatology and Craniofacial Research, vol. 3, no. 3, 2022. Accessed June 14, 2024. [Online]. Available: https://tadqiqot.uz/index.php/oral/article/view/7123
A. S. Kubaev and Sh. G. Karshiev, "Patients Associated Injuries With Fractures of the Maxillofacial Region: 118 Patients Review," Achievements of Science and Education, no. 1 (81), pp. 90-94, 2022.
R. J. Alimjanovich, Kh. J. Hayitqulovich, and R. Y. Jumayevna, "Scientific Justification of Organizational Forms of Activity of Nursing Staff of Rehabilitation Departments (Review of Literature)," European Journal of Interdisciplinary Research and Development, vol. 12, pp. 208-211, 2023.
M. X. Marupova, A. S. Kubaev, and A. I. Khazratov, "The Essential Role of Diagnostic and Treatment Methods for Patients With Temporomandibular Joint Pain Dysfunction Syndrome," World Bulletin of Public Health, vol. 10, pp. 141-142, 2022.
J. Rizaev and F. Vasikova, "The Use of Modern Technologies in the Diagnosis of Functional Disorders of the Temporomandibular Joint (Literature Review)," Central Asian Journal of Medical and Natural Science, vol. 4, no. 5, pp. 593-597, 2023, doi: https://doi.org/10.17605/cajmns.v4i5.1875.
N. A. Yarmukhamedova and J. A. Rizaev, "Study of Short-Term Adaptation to Physical Exercise in Athletes With Secondary Immunodeficiencies," Journal of Humanities and Natural Sciences, no. 6, pp.
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