Evaluation the Role of Ghrelin Hormone, D-Dimer and Biochemical Variable in Covid - 19 Patients
DOI:
https://doi.org/10.51699/ijhsms.v4i1.342Keywords:
COVID – 19, Ghrelin, D-Dimer, Lipid profileAbstract
This study was directed in the epidemiological unit of Kirkuk General Hospital - Kirkuk Health Directorate, Iraq, from January 10, 2024, to May 12, 2024. It included 83 individuals, both male and female, aged between 17 and 66 years, divided into two groups. The first group included 58 patients with confirmed COVID-19 infection, while the control group consisted of 25 healthy individuals. Tests were conducted in the virology laboratory at Kirkuk General Hospital. The results of the study indicated that COVID-19 infection significantly affected the levels of the studied variables, leading to increased levels of Ghrelin, D-Dimer, WBC, S.T-cholesterol, S.TG, S.LDL-C, S.VLDL-C, and S.Glucose, with average values of 3.757, 1949.03 ng/ml, 11.71 × 103 cells/ml, 251.40, 176.83, 197.36, 35.44, and 358.33 mg/dl for each variable, respectively. In contrast, the infection significantly reduced the levels of PCV and S.HDL-C, reaching 37.26% and 19.51 mg/dl, respectively. Additionally, the interaction between gender and age significantly affected the levels of Ghrelin, D-Dimer, PCV, and WBC, while it had no significant effect on the other studied variables.
References
kiran Bavirisetti, “Review of ‘A pneumonia outbreak associated with a new coronavirus of probable bat origin,’” Mar. 2020, ScienceOpen. doi: 10.14293/s2199-1006.1.sor-uncat.atfigj.v1.rpnimv.
L. Zhang et al., “D‐dimer levels on admission to predict in‐hospital mortality in patients with Covid‐19,” Journal of Thrombosis and Haemostasis, vol. 18, no. 6, pp. 1324–1329, Jun. 2020, doi: 10.1111/jth.14859.
G. D. Wool and J. L. Miller, “The Impact of COVID-19 Disease on Platelets and Coagulation,” Pathobiology, vol. 88, no. 1, pp. 15–27, Oct. 2020, doi: 10.1159/000512007.
S. K. Karri and S. Angappan, “Traditional Medicine as Natural Remedy in ARDS & COVID-19 Through Interleukins,” in Coronaviruses: Volume 2, BENTHAM SCIENCE PUBLISHERS, 2021, pp. 134–154. doi: 10.2174/9789814998604121020008.
D. Wang et al., “Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China,” JAMA, vol. 323, no. 11, p. 1061, Mar. 2020, doi: 10.1001/jama.2020.1585.
M. S. Valle, C. Russo, and L. Malaguarnera, “Protective role of vitamin D against oxidative stress in diabetic retinopathy,” Diabetes Metab Res Rev, vol. 37, no. 8, Mar. 2021, doi: 10.1002/dmrr.3447.
Librach, “Diet Reference Manual Massachusetts General Hospital Department of Dietetics, Little, Brown and Company, Boston: 1984 Price U.S. Dollars 14–95,” Int J Clin Pract, vol. 39, no. 8, Aug. 1985, doi: 10.1111/j.1742-1241.1985.tb07850.x.
M. Soni, R. Gopalakrishnan, R. Vaishya, and P. Prabu, “D-dimer level is a useful predictor for mortality in patients with COVID-19: Analysis of 483 cases,” Diabetes & Metabolic Syndrome: Clinical Research & Reviews, vol. 14, no. 6, pp. 2245–2249, Nov. 2020, doi: 10.1016/j.dsx.2020.11.007.
J.-W. Song et al., “Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis,” Cell Metab, vol. 32, no. 2, pp. 188-202.e5, Aug. 2020, doi: 10.1016/j.cmet.2020.06.016.
F. Sivri, M. Şencan, Ş. B. Öztürk, A. S. Maraşlı, Y. K. İçen, and Ç. Akgüllü, “Valor Prognóstico do Colesterol não HDL na Pneumonia por COVID-19,” Arq Bras Cardiol, vol. 120, no. 6, 2023, doi: 10.36660/abc.20220671.
B. Shen et al., “Proteomic and Metabolomic Characterization of COVID-19 Patient Sera,” Cell, vol. 182, no. 1, pp. 59-72.e15, Jul. 2020, doi: 10.1016/j.cell.2020.05.032.
Y.-K. Shin et al., “Ghrelin Is Produced in Taste Cells and Ghrelin Receptor Null Mice Show Reduced Taste Responsivity to Salty (NaCl) and Sour (Citric Acid) Tastants,” PLoS One, vol. 5, no. 9, p. e12729, Sep. 2010, doi: 10.1371/journal.pone.0012729.
T. Sato, Y. Nakamura, Y. Shiimura, H. Ohgusu, K. Kangawa, and M. Kojima, “Structure, regulation and function of ghrelin,” J Biochem, vol. 151, no. 2, pp. 119–128, Oct. 2011, doi: 10.1093/jb/mvr134.
E. Sanchez-Lopez et al., “Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production,” Cell Metab, vol. 29, no. 6, pp. 1350-1362.e7, Jun. 2019, doi: 10.1016/j.cmet.2019.03.011.
P. M. Ryan and N. Caplice, “COVID-19 and relative angiotensin-converting enzyme 2 deficiency: role in disease severity and therapeutic response,” Open Heart, vol. 7, no. 1, p. e001302, Jun. 2020, doi: 10.1136/openhrt-2020-001302.
A. Rezaei, S. Neshat, and K. Heshmat-Ghahdarijani, “Alterations of Lipid Profile in COVID-19: A Narrative Review,” Curr Probl Cardiol, vol. 47, no. 3, p. 100907, Mar. 2022, doi: 10.1016/j.cpcardiol.2021.100907.
J. M. Querol-Ribelles et al., “Plasma d-Dimer Levels Correlate With Outcomes in Patients With Community-Acquired Pneumonia,” Chest, vol. 126, no. 4, pp. 1087–1092, Oct. 2004, doi: 10.1378/chest.126.4.1087.
A. Poudel et al., “D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19,” PLoS One, vol. 16, no. 8, p. e0256744, Aug. 2021, doi: 10.1371/journal.pone.0256744.
L. Pan et al., “Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study,” American Journal of Gastroenterology, vol. 115, no. 5, pp. 766–773, Apr. 2020, doi: 10.14309/ajg.0000000000000620.
J. F. Osuna-Ramos et al., “Serum lipid profile changes and their clinical diagnostic significance in COVID-19 Mexican Patients,” Aug. 2020, doi: 10.1101/2020.08.24.20169789.
L. Naymagon et al., “Admission D-dimer levels, D-dimer trends, and outcomes in COVID-19,” Thromb Res, vol. 196, pp. 99–105, Dec. 2020, doi: 10.1016/j.thromres.2020.08.032.
W. Mohammedsaeed, A. M. Surrati, H. Q. Alnakhli, M. Alharbi, and N. Syeed, “Alteration of Ferritin Levels and Lymphocytes Counts in Saudi Patients with COVID-19 Infection in Al Madinah Al Munawarah,” International Journal of Diabetes and Endocrinology, vol. 5, no. 4, p. 61, 2020, doi: 10.11648/j.ijde.20200504.12.
A. galaly and K. Maulood, “Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city,” Kirkuk University Journal-Scientific Studies, vol. 0, no. 0, p. 0, Jun. 2023, doi: 10.32894/kujss.2023.137833.1093.
N. Mathur et al., “Ghrelin as an Anti-Sepsis Peptide: Review,” Front Immunol, vol. 11, Jan. 2021, doi: 10.3389/fimmu.2020.610363.
R. Mao et al., “Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis,” The Lancet Gastroenterology & Hepatology, vol. 5, no. 7, pp. 667–678, Jul. 2020, doi: 10.1016/s2468-1253(20)30126-6.
R. Lu et al., “Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding,” The Lancet, vol. 395, no. 10224, pp. 565–574, Feb. 2020, doi: 10.1016/s0140-6736(20)30251-8.
E. Logette et al., “A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19,” Front Public Health, vol. 9, Jul. 2021, doi: 10.3389/fpubh.2021.695139.
G. C. Passali and A. R. Bentivoglio, “Comment to the article ‘Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study,’” European Archives of Oto-Rhino-Laryngology, vol. 277, no. 8, pp. 2391–2392, May 2020, doi: 10.1007/s00405-020-06024-5.
J. Kuliczkowska-Płaksej et al., “Ghrelin and Leptin Concentrations in Patients after SARS-CoV2 Infection,” J Clin Med, vol. 12, no. 10, p. 3551, May 2023, doi: 10.3390/jcm12103551.
G. M. Kostner, “Letter: Enzymatic determination of cholesterol in high-density lipoprotein fractions prepared by polyanion precipitation.,” Clin Chem, vol. 22, no. 5, p. 695, May 1976, doi: 10.1093/clinchem/22.5.695a.
X. Hu, D. Chen, L. Wu, G. He, and W. Ye, “Low Serum Cholesterol Level Among Patients with COVID-19 Infection in Wenzhou, China,” SSRN Electronic Journal, 2020, doi: 10.2139/ssrn.3544826.
X. He et al., “The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients,” Sci Rep, vol. 11, no. 1, Jan. 2021, doi: 10.1038/s41598-021-81300-w.
W. Guan et al., “Clinical Characteristics of Coronavirus Disease 2019 in China,” New England Journal of Medicine, vol. 382, no. 18, pp. 1708–1720, Apr. 2020, doi: 10.1056/nejmoa2002032.
N. Y. Hakami et al., “The Effect of COVID-19 Infection on Human Blood Ghrelin Hormone: A Pilot Study,” J Pharm Res Int, pp. 33–38, Mar. 2021, doi: 10.9734/jpri/2021/v33i731199.
M. Gröschl et al., “Identification of Ghrelin in Human Saliva: Production by the Salivary Glands and Potential Role in Proliferation of Oral Keratinocytes,” Clin Chem, vol. 51, no. 6, pp. 997–1006, Jun. 2005, doi: 10.1373/clinchem.2004.040667.
A. Giacomelli et al., “Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study,” Clinical Infectious Diseases, vol. 71, no. 15, pp. 889–890, Mar. 2020, doi: 10.1093/cid/ciaa330.
E. Disse et al., “Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content,” Physiology & Behavior, vol. 101, no. 2, pp. 277–281, Sep. 2010, doi: 10.1016/j.physbeh.2010.05.017.
C. S. DiMarco, “Speroff L, Glass RH, Kase NG, editors. Clinical Gynecologic Endocrinology and Infertility. 6th ed. Baltimore: Lippincott, Williams & Wilkins, 1999:1–1200.,” Fertil Steril, vol. 74, no. 2, pp. 425–426, Aug. 2000, doi: 10.1016/s0015-0282(00)00647-6.
C. CDC Weekly, “The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020,” China CDC Wkly, vol. 2, no. 8, pp. 113–122, 2020, doi: 10.46234/ccdcw2020.032.
M. H. Dominiczak, “Tietz Textbook of Clinical Chemistry. By C.A. Burtis and E.R. Ashwood, editors,” Clin Chem Lab Med, vol. 37, no. 11–12, Jan. 1999, doi: 10.1515/cclm.2000.37.11-12.1136.
D. Barham and P. Trinder, “An improved colour reagent for the determination of blood glucose by the oxidase system,” Analyst, vol. 97, no. 1151, p. 142, 1972, doi: 10.1039/an9729700142.
A. F. Siddiqui, H. Al-Musa, H. Al-Amri, A. Al-Qahtani, M. Al-Shahrani, and M. Al-Qahtani, “Sleep Patterns and Predictors of Poor Sleep Quality among Medical Students in King Khalid University, Saudi Arabia,” Malaysian Journal of Medical Sciences, vol. 23, no. 6, pp. 94–102, 2016, doi: 10.21315/mjms2016.23.6.10.
W. M. Ali, W. M. Jasim, and Z. A. Hassan, “Association between the clinical presentation and outcome among smokers vs non- smokers COVID-19 patients in Kirkuk health care centers/Iraq,” Medical Journal of Babylon, vol. 20, no. Supplement 1, pp. S23–S30, Dec. 2023, doi: 10.4103/mjbl.mjbl_354_22.
S. Ahmad, “A Review of COVID-19 (Coronavirus Disease-2019) Diagnosis, Treatments and Prevention,” Eurasian J Med Oncol, 2020, doi: 10.14744/ejmo.2020.90853.
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