Relationship Of Thyroid Hormones, Prolactin, Leptin Level, And Some Physiological And Biochemical Parameters In Affected Women Polycystic Ovary Syndrome In Samarra City And Its Surrounding Areas

Authors

  • Khalida Khaleel Abdullah Department of Biology, College of Education, University of Samarra, Salah Al-din, Iraq
  • Asmaa Ismael Hussein Department of Biology, College of Education, University of Samarra, Salah Al-din, Iraq

DOI:

https://doi.org/10.51699/ijhsms.v3i3.76

Keywords:

Polycystic Ovaries Syndrome (PCOS), Follicular Stimulating Hormone(FSH), Luteinizing Hormone (LH), Prolactin, Leptin

Abstract

This study aimed to analyze the levels of hormones such as TSH, T3, T4, Prolactin, Leptin, LH, and FSH, as well as to assess the levels of specific antioxidants (GSH, CAT, SOD) and oxidative stress marker (MDA) in married women with polycystic ovary syndrome (PCOS) in Samarra and nearby regions. The results revealed a significant increase (P≤0.05) in the levels of Prolactin, Leptin, FSH, LH, TSH, T3, and T4, along with a rise in BMI and MDA, which indicates oxidative stress. Conversely, a significant reduction (P≤0.05) in antioxidant levels (GSH, CAT, SOD) was observed in the patients compared to the control group.

References

Hylactou M, Clarke SA, Patel B (2020). Clinical and biochemical discriminants between functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf). 2020;95:239‐252.

Akanksha Garg, Bijal Patel, Ali Abbara, and Waljit S. Dhillo (2022). Treatments targeting neuroendocrine dysfunction in polycystic ovary syndrome (PCOS). Clinical Endocrinology; 1–9.

Jia Qi (2018). Local Cortisol Elevation Contributes to Endometrial Local Cortisol Elevation Contributes to Endometrial. The Journal of Clinical Endocrinology & Metabolism, 103(7): 2457–2467.

Tiantian Zhu & Mark Goodarzi (2022). Causes and Consequences of Polycystic Ovary Syndrome: Insights From Mendelian Randomization. The Journal of Clinical Endocrinology & Metabolism, 107(3): e899–e911.

Homburg R (2002). What is polycystic ovarian syndrome? A proposal for a consensus on the definition and diagnosis of polycystic ovarian syndrome. Hum Reprod; 17-9.

Miya Ismayilova & Sanni Yaya (2022). "I felt like she didn’t take me seriously": A multi-methods study examining patient satisfaction and experiences with polycystic ovary syndrome (PCOS) in Canada. Ismayilova and Yaya BMC Women’s Health, 22:47.

McArdle D, Katchl (2000). Essentials of exercise physiology 2nd Ed. Philadelphia: Lippincott Williams Wilkins, (38).

Tietz (2006). Textbook of Clinical Chemistry and Molecular Diagnostics, 4th Edition. Elsevier Saunders Publishers, pp. 2021-2027.

Lenton E, Meal L, Sulaiman R (1982). Plasma concentrations of Human Gonadotropin from the Time of Implantation until the second week of pregnancy. Fertility and Sterility, 37:773-778. Little Brown, NY.

Vitt UA, Kloosterboer HJ, Rose UM, Mulders JW, Kiesel PS, Bete S, Nayudu PL (1998). Isoforms of human.

Guidet B, Shah S (1989). A practical guide to the assessment of ventricular diastolic pre. Am J Physiology, 257(26):440.

Hadwan MH, Kadhum Ali S (2018). New spectrophotometric assay for assessments of catalase activity in biological samples. Analytical Biochemistry, 1;542:29-33.

Al-Zamely, Mizil YO, Al-Nimer MS (2001). Detection the level of peroxynitrite and related with antioxidants status in the serum of patients with acute myocardial infarction. National J of Chemistry, (4): 625–637.

Zhang C, Bruins ME, Yang ZQ, Liu ST, Rao PF (2016). A new formula to calculate the activity of superoxide dismutase in indirect assays. Analytical Biochemistry, 503:65-67.

Sahu, Nazhan Muhammad, et al. (2021). Statistics: Mathematical Applications. Dar Al-Resala Printing, 1st edition, Iraq.

Pasquli R, Pelusi C, Genghini S, Cacciari M, Gambineri A (2003). Obesity and reproductive disorders in women. J. Hum. Repro; 9-35-72.

Jedel E, Waern M (2010). Anxiety and depression symptoms in women with polycystic ovary syndrome compared with controls matched for body mass index. Hum Reprod, 25(2): 450-456.

Recabarren SE, Smith R (2008). Metabolic profile in sons of women with Polycystic Ovary Syndrome. J. Clin. Endocrinal. Metal., 93(5):156-81.

Arita MK (2001). Regression of both pituitary and ovarian cysts after administration of thyroid hormone in a case of primary hypothyroidism. Internal Medicine, 40:751-55.

NHS Natural Health Solutions for PCOS (2004). Hypothyroidism and PCOS. Nancy Ounne, Naturopathic Physician, Bill Slater.

Loverro G, Lorusso F, Mei L, Depalo R, Cormio G, Selvaggi L (2002). The plasma homocysteine levels are increased in polycystic ovary syndrome. Gynecologic and Obstetric Investigation, 53:157-162.

Kim YW, Kim JY, Park YH, Park SY, Won KC, Choi KH, Huh JY, Moon KH (2006). Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance. Diabetes, 55:716-24.

Sepilian VP, Crochet JR, Nagamani M (2006). Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens. Fertil Steril, 85:1441-1447.

Porter MB, Brumsted JR, Sites CK (2000). Effect of prolactin on follicle stimulating hormone receptor binding and progesterone production in cultured porcine granulosa cell. Fertil. Steril., 73(1):99-105.

Panzan MQ, Junior JM, Damotta EL, Haapalainen EF, Dejesus Simoes M, Baptista HA, Haidar MA, Baracat EC (2006). Metoclopramide-induced hyperprolactinemia caused marked decline in pinopodes and pregnancy rates in mice. Hum. Reprod., 21:2514-2520.

Vale W, Wiater E, Gray P, Harrison C, Bilezikjian L, Choe S (2004). Activins and Inhibins and Their Signaling. Ann NY Acad Sci, 1038:142-147.

Altuntas CZ, Johnson JM, Tuohy VK (2006). Autoimmune targeted disruption of the pituitary-ovarian axis causes premature ovarian failure. J. Immunol., 177(3):1988-96.

Sharquic KE, AL-Bayatti AA, AL-Ajeel AI, AL-Bahar AJ, AL-Nuaimy AA (2007). Free testosterone, luteinizing hormone, follicle-stimulating hormone ratio in patients with Polycystic Ovary Syndrome. Saudi Med, 28(7):1039-43.

ASRM (American Society for Reproductive Medicine) (2007). Patient fact sheet: Hyperprolactinemia. Highway, Birmingham, Alabama 35216-2809. www.asrm.org.

Banaszewska B, Spaczyński RZ, Pelesz M, Pawelczyk L (2003). Incidence of elevated LH/FSH ratio in polycystic ovary syndrome women with normo- and hyperinsulinemia. Annales Academiae Medicae Bialostocensis, 48:132-134.

Adil F, Ansar H, Munir AA (2005). Polycystic ovarian syndrome and Hyperinsulinemia. J. Liaqat Uni Med Health Sci, 4(3):89-93.

Agarwal A, Gupta S, Sharma R (2005). Oxidative stress and its implications in female infertility: A clinician's perspective. Reprod Biomed Online, 11(5):641-50.

Sheu JY, Tseng WC, Chen MT (2003). Determination of thiobarbituric acid of Malondialdehyde using on-line microdialysis coupled with high-performance liquid chromatography. Analytical Sciences, 19:621-624.

Badizadegam (2003). Cell injury, adaptation, and death. Harvard MIT Division of Health Science & Technology, HST.035.

Espey MG, Miranda KM, Thomas DD, Zavier S, Citrin D, Vitek MP, Wink DA (2002). A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. Ann NY Acad Sci, 962:195-206.

Mishra J, Srivastava SA, Shukla A, Raghav CSR (2007). Antioxidants in aromatic and medicinal plants: Modulating in vivo activity. Sci Tech, pp. 1-16.

Block C, Dietrich M, Norkus E, Morrow JD, Poker (2002). Factors associated with oxidative stress in human populations. Am J Epidemiol., 156(3):274-278.

Gonzalez F, Rote NS, Minium J, Kirwan JP (2006). Reactive Oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab, 91(1):336-340.

Sabuncu T, Vural H, Harma M, Harma M (2001). Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease. Clin Biochem, 34(5):407-13.

Nisenblat V, Norman RJ (2009). Androgens and polycystic ovary syndrome. Curr Opin Endocrinol Diabetes Obes, 16(3):224-31.

Piotrowski P, Rzepczynski I, Kwintkiewicz J, Dule

ba AJ, Woodruff TK (2005). Oxidative stress induces expression of activin A in rat preovulatory follicles. Endocrinology, 146:1904-1911.

Chappell LC, Seed PT, Briley A, Kelly FJ, Lee R, Hunt BJ, Parmar K, Bewley SJ, Shennan AH, Steer PJ, Poston L (2002). A longitudinal study of biomarkers of oxidative stress and antioxidant status in women with preeclampsia. Am J Obstet Gynecol, 187(1):127-36.

Steiber K, Kerner J, Hoppel C (2004). Carnitine: a nutritional supplement with functional effects. J Nutr Biochem, 15: 641-649.

Cohen G, Kim M, Ogwuagor N (1996). Increased interleukin-1 protein in the rat. Biochem Pharmacol., 52(1):127-9.

Mishra J, Mishra MP, Srivastava AK, Raghav CSR (2008). Oxidative stress and obesity, clinic-pathological aspect. J Nutr., 7(1):30-34.

Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF (2001). Soluble TNF alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol., 107(1):165-70.

Fruzzetti F, Perini D, Russo M, Bucci F, Perrone G, Ghiadoni L, Mercuri A, Nannipieri M, Simoncini T (2023). Mechanisms of endothelial dysfunction in women with polycystic ovary syndrome: Focus on metabolic risk factors and therapeutic implications. Expert Rev Endocrinol Metab, 18(1): 15-23.

Selvin E, Manzi J, Stevens LA, Coresh J, Levey AS, Greene T, Van Lente F (2007). Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988-1994, 1999-2004. Am J Kidney Dis, 50:918-926.

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Published

2024-07-29

How to Cite

Khalida Khaleel Abdullah, & Asmaa Ismael Hussein. (2024). Relationship Of Thyroid Hormones, Prolactin, Leptin Level, And Some Physiological And Biochemical Parameters In Affected Women Polycystic Ovary Syndrome In Samarra City And Its Surrounding Areas. International Journal of Health Systems and Medical Sciences, 3(3), 277–285. https://doi.org/10.51699/ijhsms.v3i3.76

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