The Co-occurrence of Tuberculosis and Cardiovascular Diseases in Uzbekistan: Clinical Features and Diagnostic Approaches
DOI:
https://doi.org/10.51699/ijhsms.v4i1.214Keywords:
Tuberculosis, Cardiovascular Diseases, Co-occurrence, Uzbekistan, Pericarditis, Myocarditis, Diagnostic Challenges, Integrated Management, Healthcare Infrastructure, Qualitative ResearchAbstract
Tuberculosis (TB) and cardiovascular diseases (CVD) often co-occur in regions with high disease burdens, posing significant clinical and diagnostic challenges. However, limited research exists on the intersection of TB and CVD in resource-limited settings. This study assessed perceptions of 100 healthcare professionals in Uzbekistan, including doctors, nurses, and researchers with varying pulmonology and cardiology expertise, regarding diagnostic challenges and management strategies for concurrent TB and CVD. Using a mixed-methods approach, key findings revealed overlapping symptoms, insufficient diagnostic resources, and the frequent occurrence of TB-related pericarditis and myocarditis. Participants strongly advocated for integrated management protocols and systemic reforms, emphasizing the need for investments in diagnostic infrastructure, training programs, and public awareness. These findings underscore the necessity for further research into integrated care models and their feasibility in low-resource settings, offering valuable insights for clinical practice and policy development in regions where TB and CVD are endemic.
References
M. S. Scopazzini, K. J. Hill, E. D. Majonga, D. Zenner, H. Ayles, and A. S. V. Shah, "Imaging and Circulating Biomarker-Defined Cardiac Pathology in Pulmonary Tuberculosis: A Systematic Review," Global Heart, vol. 19, no. 1, p. 84, 2024.
C. A. Basham, S. J. Smith, K. Romanowski, and J. C. Johnston, "Cardiovascular Morbidity and Mortality Among Persons Diagnosed With Tuberculosis: A Systematic Review and Meta-Analysis," PLoS ONE, vol. 15, no. 7, 2020.
World Health Organization, Global Tuberculosis Report 2021. Geneva: WHO, 2021.
World Health Organization, "Cardiovascular Diseases (CVDs)," Available at: [https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)], accessed Nov. 20, 2024.
G. Isiguzo, E. Du Bruyn, P. Howlett, and M. Ntsekhe, "Diagnosis and Management of Tuberculous Pericarditis: What Is New?" Current Cardiology Reports, vol. 22, no. 5, p. 35, 2020.
K. Naicker and M. Ntsekhe, "Tuberculous Pericardial Disease: A Focused Update on Diagnosis, Therapy, and Prevention of Complications," Cardiovascular Diagnosis and Therapy, vol. 10, no. 2, pp. 289–298, 2020.
M. Dybowska, K. Blasinska, J. Gatarek, M. Klatt, and E. Augustynowicz-Kopec, "Tuberculous Pericarditis—Own Experiences and Recent Recommendations," Diagnostics, vol. 12, no. 3, p. 632, 2022.
USAID, "Global Health | Uzbekistan," Available at: [https://www.usaid.gov/uzbekistan/global-health], accessed Nov. 20, 2024.
World Health Organization, Global Tuberculosis Report 2021. Geneva: WHO, 2021.
World Health Organization, "Cardiovascular Diseases (CVDs)," Available at: [https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)], accessed Nov. 20, 2024.
A. Aifah, Understanding the Relationship Between Diabetes and Tuberculosis in Kazakhstan: Implications for Integrated Care and Management, Ph.D. dissertation, Columbia University, 2017.
B. T. Khalmukhamedov, "The Relevance of the Introduction of Digital Medicine Skills in the Learning Process of Medical University Students," 2022.
A. Jackson-Morris, S. Masyuko, L. Morrell, I. Kataria, E. L. Kocher, and R. Nugent, "Tackling Syndemics by Integrating Infectious and Noncommunicable Diseases in Health Systems of Low-and Middle-Income Countries: A Narrative Systematic Review," PLoS Global Public Health, vol. 4, no. 5, p. e0003114, 2024.
A. Udwadia, A. Sen, and P. Rajendran, "The Dual Burden of Tuberculosis and Cardiovascular Disease: A Clinical Conundrum," Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, vol. 28, p. 100312, 2022.
C. Anderson, P. L. Chavannes, and A. Arvanitis, "Integrated Care Pathways for Tuberculosis and Non-Communicable Diseases: Lessons from Global Implementation," International Journal of Tuberculosis and Lung Disease, vol. 27, no. 3, pp. 185–192, 2023.
J. M. Nguyen, L. H. Vo, and P. T. Tran, "Advances in Diagnostic Imaging for Tuberculosis-Related Cardiovascular Diseases," Journal of Cardiothoracic Imaging, vol. 10, no. 2, pp. 45–53, 2023.
H. Malhotra, A. Singh, and R. Dhillon, "Pericardial Effusion in Tuberculosis Patients: Emerging Trends in Resource-Constrained Settings," Global Health Research and Policy, vol. 7, no. 2, pp. 201–208, 2022.
S. Gupta, R. D. Mallick, and K. Sharma, "Cardiovascular Complications in Pulmonary Tuberculosis: A Meta-Analysis," Heart Asia, vol. 11, no. 4, pp. 301–310, 2023.
C. S. Restrepo, et al., "Thoracic Cardiovascular Complications of Tuberculosis," Journal of Computer Assisted Tomography, vol. 45, no. 1, pp. 157–165, 2021.
A. D. Mengistu, "The Intersection of Tuberculosis and Cardiovascular Disease: A Systematic Review," Ethiopian Medical Journal, vol. 57, no. 3, 2019.
